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Evading the Proteasome: Absence of Lysine Residues Contributes to Pertussis Toxin Activity by Evasion of Proteasome Degradation

Pertussis toxin (PT) is an important virulence factor produced by Bordetella pertussis. PT holotoxin comprises one enzymatically active A subunit (S1), associated with a pentamer of B subunits. PT is an ADP-ribosyltransferase that modifies several mammalian heterotrimeric G proteins. Some bacterial...

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Detalhes bibliográficos
Main Authors: Worthington, Zoë E. V., Carbonetti, Nicholas H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932868/
https://ncbi.nlm.nih.gov/pubmed/17420233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02011-06
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