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The bulge region of HIV-1 TAR RNA binds metal ions in solution

Binding of Mg(2+), Ca(2+) and Co(NH(3))(6)(3+) ions to the HIV-1 TAR RNA in solution was analysed by (19)F NMR spectroscopy, metal ion-induced RNA cleavages and Brownian dynamics (BD) simulations. Chemically synthesised 29mer oligoribonucleotides of the TAR sequence labelled with 5-fluorouridine (FU...

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Detalhes bibliográficos
Main Authors: Olejniczak, Mikołaj, Gdaniec, Zofia, Fischer, Artur, Grabarkiewicz, Tomasz, Bielecki, Łukasz, Adamiak, Ryszard W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140541/
https://ncbi.nlm.nih.gov/pubmed/12364603
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