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Structure of Gα(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

Heterotrimeric G-proteins are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive, GDP-bound and an active, GTP-bound state. Under basal conditions G-proteins exist in the i...

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Autors principals: Johnston, Christopher A., Willard, Francis S., Jezyk, Mark R., Fredericks, Zoey, Bodor, Erik T., Jones, Miller B., Blaesius, Rainer, Watts, Val J., Harden, T. Kendall, Sondek, John, Ramer, J. Kevin, Siderovski, David P.
Format: Artigo
Idioma:Inglês
Publicat: 2005
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1405235/
https://ncbi.nlm.nih.gov/pubmed/16004878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2005.04.007
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