GDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5·Vps9 System

Many GTPases regulate intracellular transport and signaling in eukaryotes. Guanine nucleotide exchange factors (GEFs) activate GTPases by catalyzing the exchange of their GDP for GTP. Here we present crystallographic and biochemical studies of a GEF reaction with four crystal structures of Arabidops...

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Detalhes bibliográficos
Main Authors: Uejima, Tamami, Ihara, Kentaro, Goh, Tatsuaki, Ito, Emi, Sunada, Mariko, Ueda, Takashi, Nakano, Akihiko, Wakatsuki, Soichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978598/
https://ncbi.nlm.nih.gov/pubmed/20833725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152132
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