Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β

Studies in humans and mice show an important role for Tregs in the control of immunological disorders. The mechanisms underlying the immunosuppressive functions of Tregs are not well understood. Here, we show that CD4(+) T cells expressing Foxp3 and membrane-bound TGF-β (TGF-β(m+)Foxp3(+)), previous...

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Autors principals: Ostroukhova, Marina, Qi, Zengbiao, Oriss, Timothy B., Dixon-McCarthy, Barbara, Ray, Prabir, Ray, Anuradha
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1401482/
https://ncbi.nlm.nih.gov/pubmed/16543950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26490
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