Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β

Studies in humans and mice show an important role for Tregs in the control of immunological disorders. The mechanisms underlying the immunosuppressive functions of Tregs are not well understood. Here, we show that CD4(+) T cells expressing Foxp3 and membrane-bound TGF-β (TGF-β(m+)Foxp3(+)), previous...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ostroukhova, Marina, Qi, Zengbiao, Oriss, Timothy B., Dixon-McCarthy, Barbara, Ray, Prabir, Ray, Anuradha
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2006
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1401482/
https://ncbi.nlm.nih.gov/pubmed/16543950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26490
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky