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Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β
Studies in humans and mice show an important role for Tregs in the control of immunological disorders. The mechanisms underlying the immunosuppressive functions of Tregs are not well understood. Here, we show that CD4(+) T cells expressing Foxp3 and membrane-bound TGF-β (TGF-β(m+)Foxp3(+)), previous...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1401482/ https://ncbi.nlm.nih.gov/pubmed/16543950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26490 |
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