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Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

The peripheral anionic site on acetylcholinesterase (AChE), located at the active center gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors; yet, the molecular mechanisms coupling this site to the active center at the gorge base to modulate catalysis remain u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Bourne, Yves, Taylor, Palmer, Radić, Zoran, Marchot, Pascale
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140045/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12505979/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg005
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