Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?

BACKGROUND: Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers, however, iodide uptake is reduced, probably as a result of decreased NIS prot...

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Autori principali: Chiefari, Eusebio, Brunetti, Antonio, Arturi, Franco, Bidart, Jean-Michel, Russo, Diego, Schlumberger, Martin, Filetti, Sebastiano
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2002
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC139985/
https://ncbi.nlm.nih.gov/pubmed/12475396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-2-35
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