Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate

Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-Å resolution r...

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Bibliografiske detaljer
Main Authors: Yeh, Brian K., Eliseenkova, Anna V., Plotnikov, Alexander N., Green, David, Pinnell, Jared, Polat, Tulay, Gritli-Linde, Amel, Linhardt, Robert J., Mohammadi, Moosa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139814/
https://ncbi.nlm.nih.gov/pubmed/12242295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7184-7192.2002
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