Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate

Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-Å resolution r...

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書目詳細資料

發表在:	Mol Cell Biol
Principais autores:	Yeh, Brian K., Eliseenkova, Anna V., Plotnikov, Alexander N., Green, David, Pinnell, Jared, Polat, Tulay, Gritli-Linde, Amel, Linhardt, Robert J., Mohammadi, Moosa
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 2002
主題:	Cell Growth and Development
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.20.7184-7192.2002
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