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Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate
Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-Å resolution r...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139814/ https://ncbi.nlm.nih.gov/pubmed/12242295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7184-7192.2002 |
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