Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate

Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-Å resolution r...

Description complète

Détails bibliographiques

Publié dans:	Mol Cell Biol
Auteurs principaux:	Yeh, Brian K., Eliseenkova, Anna V., Plotnikov, Alexander N., Green, David, Pinnell, Jared, Polat, Tulay, Gritli-Linde, Amel, Linhardt, Robert J., Mohammadi, Moosa
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2002
Sujets:	Cell Growth and Development
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.20.7184-7192.2002
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!