Structural Basis for Activation of Fibroblast Growth Factor Signaling by Sucrose Octasulfate

Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-Å resolution r...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Yeh, Brian K., Eliseenkova, Anna V., Plotnikov, Alexander N., Green, David, Pinnell, Jared, Polat, Tulay, Gritli-Linde, Amel, Linhardt, Robert J., Mohammadi, Moosa
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC139814/
https://ncbi.nlm.nih.gov/pubmed/12242295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7184-7192.2002
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares