Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements

We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a and -3b in maintaining methylation patterns in the mouse genome. Dnmt1 alone was able to maintain methylation of most CpG-poor region...

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Главные авторы: Liang, Gangning, Chan, Matilda F., Tomigahara, Yoshitaka, Tsai, Yvonne C., Gonzales, Felicidad A., Li, En, Laird, Peter W., Jones, Peter A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2002
Предметы:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC139739/
https://ncbi.nlm.nih.gov/pubmed/11756544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.2.480-491.2002
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