Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases

BACKGROUND: The Ca(2+)/calmodulin-stimulated adenylyl cyclase (AC) isoforms AC1 and AC8, couple NMDA receptor activation to cAMP signaling pathways in neurons and are important for development, learning and memory, drug addiction and persistent pain. AC1 and AC8 in the anterior cingulate cortex (ACC...

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Autors principals: Vadakkan, Kunjumon I, Wang, Hansen, Ko, Shanelle W, Zastepa, Evelyn, Petrovic, Michele J, Sluka, Kathleen A, Zhuo, Min
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395303/
https://ncbi.nlm.nih.gov/pubmed/16503978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-2-7
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