A-317491, a novel potent and selective non-nucleotide antagonist of P2X(3) and P2X(2/3) receptors, reduces chronic inflammatory and neuropathic pain in the rat

P2X(3) and P2X(2/3) receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP. A-317491 is a novel non-nucleotide antagonist of P2X(3) and P2X(2/3) receptor activation. A-317491 pot...

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Autori principali: Jarvis, Michael F., Burgard, Edward C., McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J., Subieta, Alberto, van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T., Zhu, Chang Z., Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O., Polakowski, James, Cox, Bryan F., Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC139289/
https://ncbi.nlm.nih.gov/pubmed/12482951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252537299
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