A-317491, a novel potent and selective non-nucleotide antagonist of P2X(3) and P2X(2/3) receptors, reduces chronic inflammatory and neuropathic pain in the rat

P2X(3) and P2X(2/3) receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP. A-317491 is a novel non-nucleotide antagonist of P2X(3) and P2X(2/3) receptor activation. A-317491 pot...

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Detalhes bibliográficos
Main Authors: Jarvis, Michael F., Burgard, Edward C., McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J., Subieta, Alberto, van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T., Zhu, Chang Z., Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O., Polakowski, James, Cox, Bryan F., Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139289/
https://ncbi.nlm.nih.gov/pubmed/12482951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252537299
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