Effects of A-317491, a novel and selective P2X(3)/P2X(2/3) receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

1. We have recently reported that systemic delivery of A-317491, the first non-nucleotide antagonist that has high affinity and selectivity for blocking P2X(3) homomeric and P2X(2/3) heteromeric channels, is antinociceptive in rat models of chronic inflammatory and neuropathic pain. In an effort to...

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Detalhes bibliográficos
Main Authors: McGaraughty, Steve, Wismer, Carol T, Zhu, Chang Z, Mikusa, Joseph, Honore, Prisca, Chu, Katharine L, Lee, Chih-Hung, Faltynek, Connie R, Jarvis, Michael F
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574160/
https://ncbi.nlm.nih.gov/pubmed/14623769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705574
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