Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation

Initiation factors IF2 in bacteria and eIF2 in eukaryotes are GTPases that bind Met-tRNA [Formula: see text] to the small ribosomal subunit. eIF5B, the eukaryotic ortholog of IF2, is a GTPase that promotes ribosomal subunit joining. Here we show that eIF5B GTPase activity is required for protein syn...

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Main Authors: Lee, Joon H., Pestova, Tatyana V., Shin, Byung-Sik, Cao, Chune, Choi, Sang K., Dever, Thomas E.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2002
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC139205/
https://ncbi.nlm.nih.gov/pubmed/12471154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262569399
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