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Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
Loss of the tumour suppressor BRCA1 results in profound chromosomal instability. The fundamental defect underlying this catastrophic phenotype is not yet known. In vivo, BRCA1 forms a heterodimeric complex with BARD1. Both proteins contain an N-terminal zinc RING-finger domain which confers E3 ubiqu...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139111/ https://ncbi.nlm.nih.gov/pubmed/12485996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf691 |
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