Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?

Brca1 is involved in multiple biological pathways including DNA damage repair, transcriptional regulation, and cell-cycle progression. A complex pattern of interactions of Brca1 with Trp53 has also emerged. Xu and coworkers found that haploid loss of Trp53 significantly reduces the embryonic lethali...

Full description

Saved in:
Bibliographic Details
Main Authors: McAllister, Kimberly A, Wiseman, Roger W
Format: Artigo
Language:Inglês
Published: BioMed Central 2002
Subjects:
Commentary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC138719/
https://ncbi.nlm.nih.gov/pubmed/11879563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr422
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items