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Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
Brca1 is involved in multiple biological pathways including DNA damage repair, transcriptional regulation, and cell-cycle progression. A complex pattern of interactions of Brca1 with Trp53 has also emerged. Xu and coworkers found that haploid loss of Trp53 significantly reduces the embryonic lethali...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC138719/ https://ncbi.nlm.nih.gov/pubmed/11879563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr422 |
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