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Lack of effect of nitrendipine on the pharmacokinetics and pharmacodynamics of midazolam during steady state.

1. The possible interaction (as indicated by rat experiments) between calcium channel blocking agents and benzodiazepines has been evaluated in nine healthy subjects. 2. Subsequently to an intravenous loading dose (0.07 mg kg-1) midazolam was infused for 6 h (0.035 mg kg-1 h-1) and steady state plas...

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Autors principals: Handel, J, Ziegler, G, Gemeinhardt, A, Stuber, H, Fischer, C, Klotz, U
Format: Artigo
Idioma:Inglês
Publicat: 1988
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386480/
https://ncbi.nlm.nih.gov/pubmed/3358886
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