Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis

Tristetraprolin (TTP) is a zinc-finger protein that binds to AREs (AU-rich elements) within certain mRNAs and causes destabilization of those mRNAs. Mice deficient in TTP develop a profound inflammatory syndrome with erosive arthritis, autoimmunity and myeloid hyperplasia. Previous studies showed th...

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Détails bibliographiques
Auteurs principaux: Cao, Heping, Deterding, Leesa J., Venable, John D., Kennington, Elizabeth A., Yates, John R., Tomer, Kenneth B., Blackshear, Perry J.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2006
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386027/
https://ncbi.nlm.nih.gov/pubmed/16262601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051316
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