Artificial human telomeres from DNA nanocircle templates

Human telomerase is a reverse-transcriptase enzyme that synthesizes the multikilobase repeating hexamer telomere sequence (TTAGGG)(n) at the ends of chromosomes. Here we describe a designed approach to mimicry of telomerase, in which synthetic DNA nanocircles act as essentially infinite catalytic te...

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Main Authors: Lindström, Ulf M., Chandrasekaran, Ravi A., Orbai, Lucian, Helquist, Sandra A., Miller, Gregory P., Oroudjev, Emin, Hansma, Helen G., Kool, Eric T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC138546/
https://ncbi.nlm.nih.gov/pubmed/12444252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252396199
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