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Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay

The exon junction complex (EJC) is deposited on mRNAs by the process of pre-mRNA splicing and is a key effecter of downstream mRNA metabolism. We previously demonstrated that human eIF4AIII, which is essential for nonsense-mediated mRNA decay (NMD), constitutes at least part of the RNA-binding platf...

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Autors principals: SHIBUYA, TOSHIHARU, TANGE, THOMAS Ø., STROUPE, M. ELIZABETH, MOORE, MELISSA J.
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2006 by RNA Society 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383576/
https://ncbi.nlm.nih.gov/pubmed/16495234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2190706
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