The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

Exon junction complexes (EJCs) link nuclear splicing to key features of mRNA function including mRNA stability, translation, and localization. We analyzed the formation of EJCs by the spliceosome, the physiological EJC assembly machinery. We studied a comprehensive set of eIF4A3, MAGOH, and BTZ muta...

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Hauptverfasser: Gehring, Niels H., Lamprinaki, Styliani, Hentze, Matthias W., Kulozik, Andreas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682485/
https://ncbi.nlm.nih.gov/pubmed/19478851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000120
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