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Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes
Mice lacking epidermal growth factor receptor (EGFR) develop a neurodegeneration of unknown etiology affecting exclusively the frontal cortex and olfactory bulbs. Here, we show that EGFR signaling controls cortical degeneration by regulating cortical astrocyte apoptosis. Whereas EGFR(−/−) midbrain a...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383568/ https://ncbi.nlm.nih.gov/pubmed/16467848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600988 |
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