Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1

Mitochondria-dependent apoptosis plays an important role in the embryonic development of the midbrain dopaminergic system as well as in Parkinson’s disease. Central to mitochondria-dependent apoptosis is the Bcl2 family of apoptosis-regulating proteins. However, it was unclear which Bcl2 proteins ar...

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Publicat a:Cell Death Discov
Autors principals: Robinson, Edward J., Aguiar, Sebastian P., Kouwenhoven, Willemieke M., Starmans, Dorinde S., von Oerthel, Lars, Smidt, Marten P., van der Heide, Lars P.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249233/
https://ncbi.nlm.nih.gov/pubmed/30479840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0125-7
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