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PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
PTEN, a tumor suppressor frequently inactivated in many human cancers, directly antagonizes the activity of phosphatidylinositol-3-OH kinase (PI3K) by dephosphorylating phosphoinositides. We show here that PTEN interacts directly with the NHERF1 and NHERF2 (Na(+)/H(+) exchanger regulatory factor) ho...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383560/ https://ncbi.nlm.nih.gov/pubmed/16456542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600979 |
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