MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration

Vascular endothelial growth factor-A (VEGF-A) induces actin reorganization and migration of endothelial cells through a p38 mitogen-activated protein kinase (MAPK) pathway. LIM-kinase 1 (LIMK1) induces actin remodeling by phosphorylating and inactivating cofilin, an actin-depolymerizing factor. In t...

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Hauptverfasser: Kobayashi, Miho, Nishita, Michiru, Mishima, Toshiaki, Ohashi, Kazumasa, Mizuno, Kensaku
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383554/
https://ncbi.nlm.nih.gov/pubmed/16456544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600973
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