Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe–S cluster

The generally accepted role of iron-regulatory protein 1 (IRP1) in orchestrating the fate of iron-regulated mRNAs depends on the interconversion of its cytosolic aconitase and RNA-binding forms through assembly/disassembly of its Fe–S cluster, without altering protein abundance. Here, we show that I...

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Main Authors: Clarke, Stephen L, Vasanthakumar, Aparna, Anderson, Sheila A, Pondarré, Corinne, Koh, Cheryl M, Deck, Kathryn M, Pitula, Joseph S, Epstein, Charles J, Fleming, Mark D, Eisenstein, Richard S
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383537/
https://ncbi.nlm.nih.gov/pubmed/16424901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600954
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