Mice with altered KCNQ4 K(+) channels implicate sensory outer hair cells in human progressive deafness

KCNQ4 is an M-type K(+) channel expressed in sensory hair cells of the inner ear and in the central auditory pathway. KCNQ4 mutations underlie human DFNA2 dominant progressive hearing loss. We now generated mice in which the KCNQ4 gene was disrupted or carried a dominant negative DFNA2 mutation. Alt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kharkovets, Tatjana, Dedek, Karin, Maier, Hannes, Schweizer, Michaela, Khimich, Darina, Nouvian, Régis, Vardanyan, Vitya, Leuwer, Rudolf, Moser, Tobias, Jentsch, Thomas J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383535/
https://ncbi.nlm.nih.gov/pubmed/16437162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600951
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