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Mice with altered KCNQ4 K(+) channels implicate sensory outer hair cells in human progressive deafness

KCNQ4 is an M-type K(+) channel expressed in sensory hair cells of the inner ear and in the central auditory pathway. KCNQ4 mutations underlie human DFNA2 dominant progressive hearing loss. We now generated mice in which the KCNQ4 gene was disrupted or carried a dominant negative DFNA2 mutation. Alt...

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書誌詳細
主要な著者: Kharkovets, Tatjana, Dedek, Karin, Maier, Hannes, Schweizer, Michaela, Khimich, Darina, Nouvian, Régis, Vardanyan, Vitya, Leuwer, Rudolf, Moser, Tobias, Jentsch, Thomas J
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383535/
https://ncbi.nlm.nih.gov/pubmed/16437162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600951
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