Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.

1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microso...

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Detaylı Bibliyografya
Asıl Yazarlar: Coleman, M D, Breckenridge, A M, Park, B K
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1989
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1379987/
https://ncbi.nlm.nih.gov/pubmed/2590600
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