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Structural requirements for bioactivation of anticonvulsants to cytotoxic metabolites in vitro.

The formation of cytotoxic metabolites from the anticonvulsants phenytoin and carbamazepine was investigated in vitro using a hepatic microsomal enzyme system and human mononuclear leucocytes as target cells. Both drugs were metabolised to cytotoxic products. In order to assess the structural requir...

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Détails bibliographiques
Auteurs principaux: Riley, R J, Kitteringham, N R, Park, B K
Format: Artigo
Langue:Inglês
Publié: 1989
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1380000/
https://ncbi.nlm.nih.gov/pubmed/2590607
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