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Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.

1. A two compartment system, comprising two adjacent teflon chambers separated by a semi-permeable membrane, has been devised with which to investigate the generation of drug metabolites that are toxic to human cells in vitro. 2. Compartment A contained a drug-metabolising system (human liver micros...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Riley, R J, Roberts, P, Coleman, M D, Kitteringham, N R, Park, B K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1990
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368145/
https://ncbi.nlm.nih.gov/pubmed/2223420
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