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Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.
1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microso...
Shranjeno v:
| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1989
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1379987/ https://ncbi.nlm.nih.gov/pubmed/2590600 |
| Oznake: |
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