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A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export

The HIV-1 Rev protein is an essential regulator of the HIV-1 mRNA expression that promotes the export of unspliced and partially spliced mRNA. The export receptor for the leucine-rich nuclear export signal (NES) of Rev has recently been recognized as CRM1. We identified a low molecular weight compou...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Daelemans, Dirk, Afonina, Elena, Nilsson, Jakob, Werner, Gudrun, Kjems, Jørgen, De Clercq, Erik, Pavlakis, George N., Vandamme, Anne-Mieke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2002
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137902/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12374846/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212285299
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