An Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes

Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the biology of aneuploidies, we manipulated mouse embryonic stem cells and generated a trans-species aneuploid mouse line that stably transmits a...

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Autors principals: O’Doherty, Aideen, Ruf, Sandra, Mulligan, Claire, Hildreth, Victoria, Errington, Mick L., Cooke, Sam, Sesay, Abdul, Modino, Sonie, Vanes, Lesley, Hernandez, Diana, Linehan, Jacqueline M., Sharpe, Paul T., Brandner, Sebastian, Bliss, Timothy V. P., Henderson, Deborah J., Nizetic, Dean, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C.
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1378183/
https://ncbi.nlm.nih.gov/pubmed/16179473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1114535
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