An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

BACKGROUND: Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic cause of mental retardation in humans. Among complex phenotypes, it displays a number of neural pathologies including smaller brain size, reduced numbers of neurons, reduced dendritic spine d...

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Bibliografiske detaljer
Main Authors: Mensah, Afua, Mulligan, Claire, Linehan, Jackie, Ruf, Sandra, O'Doherty, Aideen, Grygalewicz, Beata, Shipley, Janet, Groet, Juergen, Tybulewicz, Victor, Fisher, Elizabeth, Brandner, Sebastian, Nizetic, Dean
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211317/
https://ncbi.nlm.nih.gov/pubmed/18047653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-7-131
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