DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

Down syndrome (DS) is the most common cause of mental retardation. Many neural phenotypes are shared between DS individuals and DS mouse models; however, the common underlying molecular pathogenetic mechanisms remain unclear. Using a transchromosomic model of DS, we show that a 30%–60% reduced expre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Canzonetta, Claudia, Mulligan, Claire, Deutsch, Samuel, Ruf, Sandra, O'Doherty, Aideen, Lyle, Robert, Borel, Christelle, Lin-Marq, Nathalie, Delom, Frederic, Groet, Jürgen, Schnappauf, Felix, De Vita, Serena, Averill, Sharon, Priestley, John V., Martin, Joanne E., Shipley, Janet, Denyer, Gareth, Epstein, Charles J., Fillat, Cristina, Estivill, Xavier, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Antonarakis, Stylianos E., Nizetic, Dean
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556438/
https://ncbi.nlm.nih.gov/pubmed/18771760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.08.012
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