NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice

NCX-1015 is a nitric oxide (NO)-releasing derivative of prednisolone. In this study we show NCX-1015 protects mice against the S. A. development and induces healing of T helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNB...

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Главные авторы: Fiorucci, Stefano, Antonelli, Elisabetta, Distrutti, Eleonora, Del Soldato, Piero, Flower, Roderick J., Clark, Mark J. Paul, Morelli, Antonio, Perretti, Mauro, Ignarro, Louis J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2002
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC137791/
https://ncbi.nlm.nih.gov/pubmed/12427966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.232583599
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