21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties

1. Anti-inflammatory effects of a novel derivative of the glucocorticoid prednisolone were investigated. NCX-1015 (prednisolone 21-[(4′-nitrooxymethyl)benzoate]) incubation in human platelet-rich plasma produced a time (0–60 min) and concentration (3–300 μM) dependent release of nitrite, that was mi...

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Bibliographic Details
Main Authors: Paul-Clark, Mark, Del Soldato, Piero, Fiorucci, Stefano, Flower, Roderick J, Perretti, Mauro
Format: Artigo
Language:Inglês
Published: 2000
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572462/
https://ncbi.nlm.nih.gov/pubmed/11090106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703704
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