Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance. Most patients have a heterozygous mutation in the APT1 gene, which encodes Fas (CD95, APO-1), mediator of an apoptotic pathway crucial to lymphocyte homeostasis. Of 17 unique APT1 muta...

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Autores principales: Jackson, C E, Fischer, R E, Hsu, A P, Anderson, S M, Choi, Y, Wang, J, Dale, J K, Fleisher, T A, Middelton, L A, Sneller, M C, Lenardo, M J, Straus, S E, Puck, J M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377824/
https://ncbi.nlm.nih.gov/pubmed/10090885
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