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The hemochromatosis protein HFE inhibits iron export from macrophages
Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expresse...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137763/ https://ncbi.nlm.nih.gov/pubmed/12429850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242614699 |
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