The hemochromatosis protein HFE inhibits iron export from macrophages

Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expresse...

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Bibliographic Details
Main Authors: Drakesmith, Hal, Sweetland, Emma, Schimanski, Lisa, Edwards, Jon, Cowley, Diana, Ashraf, Mubeen, Bastin, Judy, Townsend, Alain R. M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC137763/
https://ncbi.nlm.nih.gov/pubmed/12429850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242614699
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