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HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis
The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeosta...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1180511/ https://ncbi.nlm.nih.gov/pubmed/16043695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504823102 |
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