Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection

We have recently reported that the mean number of CCR5 coreceptors at the surface of CD4(+) T cells (CCR5 density) correlates with viral load and disease progression in HIV-1-infected persons. Here, we definitively establish that CCR5 density determines the level of virus production and identify the...

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Detalles Bibliográficos
Autores principales: Lin, Yea-Lih, Mettling, Clément, Portales, Pierre, Reynes, Jacques, Clot, Jacques, Corbeau, Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC137761/
https://ncbi.nlm.nih.gov/pubmed/12434015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242134499
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