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High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading
Mutations are a hallmark of cancer. Normal cells minimize spontaneous mutations through the combined actions of polymerase base selectivity, 3′ → 5′ exonucleolytic proofreading, mismatch correction, and DNA damage repair. To determine the consequences of defective proofreading in mammals, we created...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137756/ https://ncbi.nlm.nih.gov/pubmed/12429860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.232340999 |
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