DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice

Organisms require faithful DNA replication to avoid deleterious mutations. In yeast, replicative leading- and lagging-strand DNA polymerases (Pols ε and δ, respectively) have intrinsic proofreading exonucleases that cooperate with each other and mismatch repair to limit spontaneous mutation to less...

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Hauptverfasser: Albertson, Tina M., Ogawa, Masanori, Bugni, James M., Hays, Laura E., Chen, Yang, Wang, Yanping, Treuting, Piper M., Heddle, John A., Goldsby, Robert E., Preston, Bradley D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761330/
https://ncbi.nlm.nih.gov/pubmed/19805137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907147106
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